What is Majestem®?

Discover how Majestem® uses plant cell culture to harness the natural powers of Edelweiss and manufacture a premium skin-tightening ingredient in a sustainable way.

What is Majestem®?

Majestem® is an active ingredient derived from the alpine flower, Edelweiss. It provides visible skin lifting, including tightening sagging neck skin, lifting the cheeks and smoothing out crow's feet wrinkles around the eye area, while also helping to protect against oxidative stress from UV exposure and pollution. 

Wild Edelweiss is a protected species that thrives in steep, remote mountainous areas in the European Alps. Instead of extracting compounds from crops of harvested flowers, Croda uses plant cell culture technology to create a lab-grown source of Majestem®’s active compound, Leontopodium alpinum. This not only ensures a sustainable supply but provides batch-to-batch consistency that is not impacted by bad harvests, weather or pollution.  

Scientist cutting plant tissue culture in petri dish, performing laboratory experiment

What is the science powering Majestem®? 

In nature, Edelweiss survives in extreme high-altitude environments with intense UV radiation, low temperatures, and high oxidative stress. To cope, it produces antioxidant and photoprotective compounds that help protect its cells from environmental damage. 

Majestem® harnesses these Edelweiss-derived molecules to help protect skin cells from similar oxidative stress, which can contribute to visible signs of ageing. 

Most anti-ageing products focus on trying to make more collagen. Majestem® takes a broader approach by helping the skin's own repair system work more effectively. 

Every skin cell has tiny structures called mitochondria, which generate the energy needed for the cell to perform its daily jobs, including producing collagen and repairing damaged tissue. By supporting normal cellular activity in the skin, Majestem® helps the skin maintain its natural structure and resilience. 

Is Majestem® an industry gamechanger?  

Clinical evaluations by Croda show that Majestem® achieves visible improvements in the appearance of skin firmness and texture. In just three weeks, sagging neck skin is significantly tightened, and neck folds even out. After six weeks, tests showed cheeks were visibly lifted, and crow’s feet wrinkles smoothed out. 

Alongside its strong functional performance, Majestem®’s manufacture using plant cell culture ensures a consistent, traceable and sustainable supply of bioactive compounds in the lab, reducing the pressure on agricultural land and supply chain volatility.  

Using plant cell culture to make Majestem® also ensures Edelweiss is not overharvested and aligns with demand from consumers and the beauty industry for nature-derived ingredients.  

Majestem® has an in-cosmetics Silver Green Ingredient Award, highlighting its potential to redefine how premium cosmetic actives are developed and manufactured.

Explore the biotech and trends creating innovative new actives for skincare and longevity below.

plant cell culture in a lab

Cécile Jonchier, Research Manager, Croda Beauty

"Plant cell culture allows us to take inspiration from nature and unlock entirely new possibilities for beauty innovation, creating ingredients that are both highly effective and more sustainable."
Find out more from Cécile Jonchier